Profundus Imaging

Research and collaborations

The research team, with support from the Marcus and Amalia Wallenberg Memorial Fund and VINNOVA - the Swedish Government Innovation  Agency, has developed a unique dual conjugate,adaptive optics, retinal imaging, proof-of-concept prototype for high resolution wide-field images of the human retina. The use of adaptive optics enables the prototype to acquire retinal images with a resolution on the order of a few micrometers, approximately 8-10 times better than the 15-20 µm achievable with conventional retinal imaging instruments.

The implementation of multi-conjugate adaptive optics allows for adaptive optics corrected imaging over a retinal area of 7x7 deg. 

The first demonstrator design has been optimized and miniaturized into a transportable desktop proof-of-concept prototype that is designed for clinical use. A clinical validation phase has been initiated to verify clinical relevance in comparison with established clinical methodologies. The overall purpose is to image patients with retinal disease and look for currently sub-clinical signs of retinal disease in e.g. diabetic retinopathy and other retinal vascular diseases, age-related macular degeneration, inflammatory conditions, glaucoma, and inherited retinal degenerations.


Thaung J, Knutsson P, Popovic Z, Owner-Petersen M. Dual-Conjugate Adaptive Optics for Wide-Field High-Resolution Retinal Imaging. Optics Express. 2009;17(6): 4454-4467.

Popovic Z, Knutsson P, Thaung J, Owner-Petersen M,
Sjostrand J.  Noninvasive Imaging of Human Foveal Capillary Network Using Dual-Conjugate Adaptive Optics. Investigative Ophthalmology & Visual Science. 2011;52(5):2649-2655.

Popovic Z, Thaung J, Knutsson P, Owner-Petersen M.

Dual Conjugate Adaptive Optics Prototype for Wide Field High Resolution Retinal Imaging, Adaptive Optics Progress, Dr. Robert Tyson (Ed.), ISBN: 978-953-51-0894-8, InTech, DOI: 10.5772/53640.

Popović Z, Owner-Petersen M, and Thaung J. (2011)

Non-invasive dual-conjugate adaptive optics imaging of human foveal capillary network. Engineering the Eye III, Benasque, Spain.


Popovic Z, Thaung J, Svensson B, Owner-Petersen M.

Evaluation of a Dual-Conjugate Adaptive Optics Clinical Prototype for Retinal Imaging, ARVO Meeting Abstracts June 16, 2013 54:5548

Popović Z, Owner-Petersen M, and Thaung J. (2006)

Wide-field dual-conjugate adaptive optics instrument for retinal imaging. Engineering the Eye II: Imaging the Retina, Galway, Ireland.

Thaung J, Popović Z, and Owner-Petersen M. (2007)

Dual-conjugate adaptive optics instrument for wide-field retinal imaging. The 6th International Workshop on Adaptive Optics for Industry and Medicine, Galway, Ireland.

Sjöstrand J, Knutsson P, Popović Z, and Thaung J. (2009)

Clinically useful wide-field high-resolution retinal imaging with a dual-conjugate adaptive optics instrument. EVER, Portorož, Slovenia.