There are over 1 billion individuals globally that suffer from a vision impairment that could have or has yet to be prevented. There is a strong demand for imaging of retinal structures on a cellular level, such as photoreceptors and capillaires, in order to improve diagnosis of retinal disease and prevent vision loss.
We will make a difference
Retinal disease in general affects the structural integrity of the retina. Early detection of such structural changes is therefore in high demand in order to minimize disease induced damage and suffering.
Several diseases give changes in the retina, one example is diabetes. Diabetic eye screening test can find problems before they affect the sight. The earlier problems are found the earlier treatment and life style changes can be recommended.
The Profundus Guide Star System will be customized with different modules that will improve clinical workflow and save valuable time. Image post-processing and longitudinal trend reports will facilitate evaluation and follow-up.
Profundus AB was founded on the results of research and development of a unique instrument for wide-field high-resolution adaptive optics retinal imaging, by the Adaptive Optics research team at the Department of Ophthalmology, University of Gothenburg.
The prototype features a 7x7 deg corrected field-of-view that enables the user to quickly cover larger retinal areas. An 11x11 deg mosaic can easily be obtained using only five images. The diagnostic benefit of the proof-of-concept prototype is currently being documented in a clinical research program.
Our aim is to provide researchers and clinicians with a tool that can visualize currently subclinical changes of retinal disease.
The key feature of the Profundus instrument is the Adaptive Optics (AO) system used for compensating the ocular aberrations when imaging the human retina in vivo. In contradiction to conventional AO, our system makes use of two deformable mirrors controlled by sensing the wavefronts of five guide stars. This feature is a special case of the so-called Multi Conjugate Adaptive Optics (MCAO), where several guide stars control several deformable mirrors. The inventor of the principle of MCAO was Jacques Beckers (1934-2021). MCAO is currently being implemented on several of the large telescopes of today, with the purpose of extending the size of the corrected field, as is also the case for our retinal images. Jacques was a huge inspirer and a much-appreciated friend of the Profundus team. It is only fair to claim that without Jacques there would be no Profundus instrument.
Partners and collaborations